Affiliation:
1. Imam Abdulrahman Bin Faisal University
2. Sudan University of Science and Technology
Abstract
Abstract
Introduction: B-acute lymphoblastic leukemia (B-ALL) is a heterogenous disease that has diverse immature cell phenotypes early detection of high-risk groups. The aim of this study was to predictive scoring system using a fully standardized Euroflow eight-color panel.
Methods:The expression of the different CD markers involved in the B-ALL Euroflow panel was investigated by measuring their positivity, percentage, and median fluorescence intensity.
Results: CD9, CD123, and TdT were used to predict TCF3PBX1 with 80% SN and 100% SP. CD20 and CD66 were used to predict hypoploidy with 63% SN and 100% SP. As a result, no useful discriminative scoring system was developed.
Conclusion: Four scoring systems were proposed for the prediction of the most common cytogenetic abnormalities of Saudi B-ALL
Publisher
Research Square Platform LLC