Simulation and experimental study on vascular hemodynamics of atherosclerotic plaque

Abstract

Abstract For atherosclerotic diseases, a large number of associated plaque rather than single plaque are found in diseased vessels during clinic diagnosis. For the study of hemodynamic parameters, this paper uses a simplified model to simulate the fluid-structure interaction during a non-Newtonian blood flowing through arteries with different degrees of stenosis caused by atherosclerosis. The influence of the geometry and location of the anterior plaque on the hemodynamic parameters of the posterior plaque have mainly been discussed. The effects of fluid wall shear stress, gradient, normal stress and shear rate on the posterior plaque were studied by changing of the plaque spacing, the stenosis rate, the spatial angle in diseased artery. The simulation results obtained by the ideal model can reveal more complex blood flow characteristics of arterial stenosis. It shows that with the increase of plaque spacing, V, WSS, WNS and SR increased by an average of about 3.2–6.6%. And when δ1 > 60%, the variables V, WSS, WNS, SR, and WSSG increase by more than 37%.These findings are of great significance to the development and prediction of plaque rupture in the diseased vessels.