Abstract
Background:
The positive correlation between embryo quality and pregnancy outcomes has been well confirmed in many studies, but few studies have investigated the impact of embryo quality on neonatal weight, especially among neonates from fresh IVF-ET cycles in ART. So the objective of the article was to compare the birth weights of infants from different blastocyst grades in fresh IVF-ET cycles and to explore related factors affecting birth weight.
Methods:
A retrospectively cohort study was performed to compare the birth weight of different blastocyst grades in fresh transplantation cycle and explore the related factors affecting the birth weight. A total of 1301 fresh cycles of single blastocyst transplantation and single live birth profile were retrospectively analyzed and were grouped into four groups depending on the blastocyst quality: excellent group(grade AA) 170 cycles, good group༈grade AB/BA༉312 cycles, average group༈grade BB/CA/AC༉ 559 cycles and poor group༈grade BC/CB༉260 cycles. Comparison among four groups of patients by birth weight and general conditions, fertilization rate, embryo rate, cleavage rate and D5、D6 blastocyst formation rate and other laboratory indicators were made. And then compare the birth weight of different groups which were divided by the degree of blastocyst expansion, and the classification of intracellular mass(ICM) and extracellular trophoblastic(TE).
Results:
The study showed that birth weight of excellent group was significantly higher than that of the other three groups (P < 0.05). And the high quality embryo rate and blastocyst rate of excellent group were significantly higher than those of the other three groups (P < 0.05). What’s more, the clinical pregnancy rate, implantation rate and live birth rate of high grade blastocyst were higher, but there was no significant difference in abortion rate. The birth weight of blastocyst of grade 3 and below was significantly lower than that of those with grade 3 and above (P < 0.05).The birth weight of grade A intracellular mass was significantly higher than that of B intracellular mass of blastocyst(P < 0.05). Babies born with grade B ectotrophoblast cells were significantly heavier than those born with grade C ectotrophoblast cells(P < 0.05).
Conclusion:
The authors conclude that high grade blastocyst transplantation can achieve better pregnancy outcome. Different blastocyst grades affect birth weight, and low grade blastocyst transplantation was associated with a single birth weight loss.