Weighted Ordinal Connection based Functional Network Classification for Schizophrenia Disease Detection using EEG signal

Abstract

Abstract A brain connectivity network (BCN) is an advanced approach for examining brain functionality in various conditions. However, the predictability of the BCN is affected by the connectivity measure used for the network construction. Various connectivity measures available in the literature differ according to the domain of their working data. The application of random connectivity measures might result in an inefficient BCN that ultimately hamper its predictability. Therefore, selecting an appropriate functional connectivity metric is crucial in clinical as well as cognitive neuroscience. In parallel to this, an effective network identifier plays a vital role in distinguishing different brain states. Hence, the objective of this paper is two-fold, which includes identifying suitable connectivity measures and proposing an efficient network identifier. For this, the weighted BCN (WBCN) is constructed using multiple connectivity measures like correlation coefficient (r), coherence (COH), phase-locking value (PLV), and mutual information (MI) from electroencephalogram (EEG) signals. The most recent technique for feature extraction, i.e., weighted ordinal connections, has been applied to EEG-based BCN. EEG signals data has been taken from the schizophrenia disease database. Further, several classification algorithms such as k-nearest neighbours (KNN), support vector machine (SVM) with linear, radial basis function and polynomial kernels, random forest (RF), and 1D convolutional neural network (CNN1D) are used to classify the brain states based on extracted features. In classification, 90% accuracy is achieved by the CNN1D classifier with WBCN based on the coherence connectivity measure. The study also provides the structural analysis of the BCN.