Affiliation:
1. Amrita School of Biotechnology: Amrita Vishwa Vidyapeetham Amrita School of Biotechnology
Abstract
Abstract
Heat Shock Protein 90 (HSP90) and long non-coding RNAs
(LncRNAs) are found to be upregulated in human cancer cells and
play a significant role in cancer progression and aggression. The
lncRNAs have the capability to interact with coding regions of
genes, RNA and proteins as well as regulate their functions. Here,
we sought to study the lncRNAs in HSP90 gene interactions with
HSP90 protein to identify the structural dynamics of HSP90.
Furthermore, we attempted to find the potential phytochemicals
targeted to HSP90 protein as potential anticancer drugs. It was
observed that theaflavin, epigallocatechin gallate, procyanidin,
rutin and myricetin are potential anticancer drugs. These
phytochemicals can be validated by in vitro studies in the
future.
Publisher
Research Square Platform LLC
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