Safety of Bubble Nasal Intermittent Positive Pressure Ventilation (NIPPV) versus Bubble Nasal Continuous Positive Airway Pressure (NCPAP) in preterm infants with respiratory distress

Author:

John Stephen1,Garg Mehak2,Muttineni Mounika1,Brearley Ann1,Rao Praveen,Bhandari Vineet3ORCID,Slusher Tina,Murki Srinivas4

Affiliation:

1. University of Minnesota

2. Paramitha Women and Children's Hospital

3. The Children's Regional Hospital at Cooper/CMSRU

4. Fernandez Hospital

Abstract

Abstract Objective Nasal Intermittent Positive Pressure Ventilation (NIPPV) is an effective therapy for infants in respiratory distress. We here report the safety of a novel, low-cost, non-electric bubble NIPPV device in comparison with bubble NCPAP.Study Design: At Paramitha Children’s Hospital (Hyderabad, India), preterm (n = 60) neonates with moderate respiratory distress were pragmatically allocated to bubble NCPAP (5–8 cm H2O) or bubble NIPPV (Phigh 8–12 cm H2O/Plow 5–8 cm H2O) based on staff and equipment availability. Primary outcomes to assess safety included clinically relevant pneumothorax, nasal septal necrosis, or abdominal distention.Results One patient in each arm developed minor nasal septal injury (grade 3 on NCPAP, grade 2 on NIPPV); no patients in either arm developed a clinically significant pneumothorax or abdominal distention.Conclusion The similar rates of nasal septal injury, pneumothorax and abdominal distention suggest that bubble NIPPV has a similar safety profile as bubble NCPAP for preterm infants in respiratory distress.

Publisher

Research Square Platform LLC

Reference21 articles.

1. 4 million neonatal deaths: when? Where? Why?;Lawn JE;The lancet,2005

2. Global, Regional and National Trends in the Burden of Neonatal Respiratory Failure and essentials of its diagnosis and management from 1992 to 2022: a scoping review;Tochie JN;European Journal of Pediatrics,2023

3. MacDonald MG, Ramasethu J, Rais-Bahrami K. Atlas of procedures in neonatology. Lippincott Williams & Wilkins; 2012.

4. A comparison of underwater bubble continuous positive airway pressure with ventilator-derived continuous positive airway pressure in premature neonates ready for extubation;Lee KS;Neonatology,1998

5. Efficacy and safety of bubble CPAP in neonatal care in low and middle income countries: a systematic review;Martin S;Archives of Disease in Childhood-Fetal and Neonatal Edition,2014

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