Non-chromatographic method for the purification of high purity paclitaxel from Taxus chinensis using tandem cavitation fractional precipitation

Author:

Kang Da-Yeon1,Kim Jin-Hyun2ORCID

Affiliation:

1. Kongju National University

2. Kongju National University

Abstract

Abstract In this study, a non-chromatographic method using tandem cavitation fractional precipitation was developed for the purification of high-purity paclitaxel. Paclitaxel was purified with a purity of 98.8% and an overall yield of 91.1% through a three-step fractional precipitation using acetone/pentane (1:9, v/v), methanol/water (61.5:38.5, v/v), and acetone/water (1:2, v/v) systems. In addition, the precipitation characteristics and step-by-step impurity removal behaviors were observed using RP-HPLC, and the structure of the paclitaxel purified by tandem cavitation fractional precipitation was identified using FT-IR spectroscopy.

Publisher

Research Square Platform LLC

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