Case Report: An HIV-Positive Woman Diagnosed with ALK Rearranged Lung Large-Cell Neuroendocrine Cancer with Unusual Metastasis

Author:

Kang Hong1,Li Fei2,Ye Wangzhong1,Wu Shizhen2,Yang Tian3

Affiliation:

1. Sichuan University

2. Nanping First Hospital Affiliated to Fujian Medical University

3. Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Abstract

Abstract Background Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is an exceedingly rare and aggressive type of lung cancer, often associated with metastasis to the brain, bones, adrenal glands and lymph nodes. To date, only a few cases of lung LCNEC with breast metastasis have been reported. Anaplastic lymphoma kinase (ALK) rearrangements occur in lung adenocarcinomas, but they are not typical for LCNEC and the median survival of LCNEC patients is approximately 1 year. Case presentation Here, we presented the case of an HIV-positive woman who was diagnosed with ALK-positive lung LCNEC from breast nodules. The patient responded dramatically to alectinib treatment. She showed an evidently longer median survival time than that reported previously, which suggests the benefit of using ALK inhibitors. Conclusions Based on our case experience, we recommend next-generation sequencing (NGS) as a routine procedure for patients with LCNEC as it can provide more numbers of therapeutic alternatives.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3