Abstract
Objective: The objective of this study was to explore whether there was a causal relationship between educational attainment (EA) and supraventricular tachycardia (SVT) using Mendelian randomization (MR) analysis.
Method: A two‐sample Mendelian randomization (MR) analysis using the inverse‐
variance weighted (IVW), weighted median, MR‐Egger regression, simple model, weighted mode and MR pleiotropy residual sum and outlier (MR-PRESSO) methods were performed. A mediation analysis using multivariate MR methods was also conducted. We used the publicly available summary statistics data sets of genome‐ wide association studies (GWAS) meta‐analyses for EA in individuals of European descent (n = 766 345; SSGAC consortium) as the exposure and a GWAS for Diagnoses - main ICD10: I47.1 SVT from the individuals included in the UK Biobank (total n = 463 010; case = 1306, control = 461704) as the outcome.
Results: The IVW analysis results supported an inverse causative association between EA and SVT (β=−0.0018, SE=0.00066, p=0.0066), which was consistent with the results of weighted median, as well as MR-PRESSO. Common cardiovascular risk factors such as body mass index (BMI), type 2 diabetes mellitus (T2DM), systolic blood pressure (SBP) and smoking behaviour did not mediate the association between EA and SVT.
Conclusion: The results of MR analysis suggest a potential negative causal association between EA and the occurrence of SVT.