Examining The Correlation between Patients with Atrial Fibrillation and eNOS G894 T Polymorphism

Abstract

Abstract Objectives Atrial fibrillation (AF) is the most common sustained arrhythmia. AF is a serious health problem since it causes discomfort, heart failures and strokes in patients. This study aims to identify the possible role of eNOS G894T polymorphisms in AF incidents. Methods 73 individuals were included in the study with age average of 63.47 ± 9.10 who received EKG (electrocardiogram) at Elazig Training and Research Hospital Cardiology Department. 92 individuals with age average of 60.71 ± 9.14 who were confirmed to have no heart condition were included in the study as control group. The genomic DNAs of Control and AF groups were isolated from full blood. eNOS G894T polymorphism was detected with a real-time PZR device using kits. This study was conducted between the 2018 march and December. ethics committee university ethics committee 04/09/2018 Received with the management number 279476. This study was conducted between September and December 2018. It was received with the letter of the Ethics Committee of Fırat University Ethics Committee dated 04/09/2018 and numbered 279476. Results The significance of hypertension between AF patient and control groups was detected (p < 0,023), yet no significance was detected between diabetes, smoking and body mass index ((p > 0,004). Significant difference was observed between control group and AF group regarding eNOS G894T polymorphism (p < 0.0001). Conclusions As a result, it is concluded that variants of eNOS G894 T can be considered as a risk factor for AF.