Comparative Study of Bi2 O3 , MgO and ZrO2 Nanomaterials designed by Polymer Sacrificial Method for Amoxicillin delivery and Bone Regeneration: In-Vitro Studies

Abstract

Abstract Hard tissue scientists face many difficulties, including persistent osteomyelitis and diseased bone abnormalities. Inorganic mesoporous nanomaterials are excellent candidates for the adsorption and loading of bioactive medicinal substances because to their chemical-physical characteristics. Recently, zirconium oxide, magnesium oxide and bismuth oxide nanoparticles are of great surface area and biocompatibility, and they have been described as a new drug delivery carrier. In this study, amoxicillin antibiotic was loaded into the prepared mesoporous nanomaterials (ZrO2, MgO and Bi2O3) to form a local antibiotic delivery system. The prepared mesoporous nanomaterials were investigated by XRD, FTIR, TEM, zeta potential and BET surface area measurements. Amoxicillin antibiotic was released from the prepared mesoporous nanomaterials in PBS. The effectiveness of the antibacterial study against several gram-positive and gram-negative bacterial strains was assessed. The cytotoxicity study of the human osteoblast-like cells (MG-63) was tested for all prepared mesoporous nanomaterials utilizing MTT assay. ZrO2 demonstrated particle diameters in the range of (5.26– 11.47nm), MgO was (70–80nm) and Bi2O3 was (9.79– 13.7nm). The greater surface area was confirmed for Bi2O3 sample (3.99 m2g− 1) by BET surface area. Amoxicillin loaded mesoporous nano powders exhibited impressive antibacterial and antifungal activities. MgO and Bi2O3 mesoporous nanoparticles exhibited better antimicrobial activities compared to ZrO2 sample. The proliferation for all samples gave good results especially for MgO and Bi2O3. As a result, the produced mesoporous nanomaterials have a significant potential for use as medicine delivery systems for bone regeneration and for enhancing the properties of other products in medical applications.