A redox-related lncRNA signature in bladder cancer

Author:

Zhao Fuguang1,Xie Hui2,Guan Yawei1,Teng Jingfei1,Li Zhihui3,Gao Feng3,Luo Xiao3,Ma Chong1,Ai Xing1

Affiliation:

1. The Third Medical Center, Chinese People’s Liberation Army (PLA) General Hospital

2. The First Affiliated Hospital of Fujian Medical University

3. The Seventh Medical Center, Chinese People’s Liberation Army (PLA) General Hospital

Abstract

Abstract

Redox status is closely associated with the development and progression of cancer, which can be modulated by long non-coding RNA (lncRNA). A series of previous studies have demonstrated that redox regulation can be treated as a potential treatment option for cancer. However, the redox-related lncRNA predictive signature of bladder cancer (BCa) still remains unknown. The purpose of our study is to construct a redox-related lncRNA signature for better prediction of BCa patients’ prognosis. We downloaded transcriptome and clinical data from the Cancer Genome Atlas (TCGA) database. The prognostic redox-related lncRNAs were identified by univariate Cox regression, least absolute shrinkage and selection operator (LASSO) regression, and multivariate Cox regression analysis and two risk groups were established. A comprehensive analysis corresponding to clinical features between high-risk and low-risk groups was conducted. Eight redox-lncRNAs (AC018653.3, AC090229.1, AL357033.4, AL662844.4, AP003352.1, LINC00649, LINC01138, MAFG-DT) were selected and constructed the risk model. The overall survival (OS) in high-risk group was worse than that in low-risk group (p < 0.001). The redox-related lncRNA signature has a better predictive accuracy than clinicopathological characteristics. GSEA analysis showed the MAPK signaling pathway and WNT signaling pathway were enriched in the high-risk group. Compared with the low-risk group, the patients in high-risk group were more sensitive to cisplatin, docetaxel, and paclitaxel. Furthermore, IGF2BP2, a potential target gene of MAFG-DT, was overexpressed in tumor tissues and was correlated with OS. Our study proved that the predictive signature constructed by eight redox-related lncRNAs can independently and accurately predict the prognosis of BCa patients.

Publisher

Springer Science and Business Media LLC

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