A-scan parameters and risk of phacomorphic glaucoma among kazakh population

Abstract

Abstract Purpose: The aim of our study was to identify risk factors parameters associated with PG in patients with mature cataract by comparing biometric parameters of contralateral eyes of patients with PG with eyes of patients with mature cataract.Methods: This retrospective case - control study included 71 affected eyes with PG, 311 eyes of control participants and 71 contralateral eyes with PG. All participants were ethnically Kazakh. Axial length (AL), anterior chamber depth (ACD), lens thickness (LT) were measured using A-scan ultrasound biometry. To determine the cut-off value of the A-scan parameters associated with PG, we performed ROC analysis. Results: The eyes with PG had the smallest AL, ACD and the largest LT, followed by the fellow eyes with PG and control eyes. There were no differences in age and sex between patients with PG and mature cataract. After adjustment for age and other A-scan parameters, continuous measures of AL and LT were associated with PG (OR 0.57, 95% CI 0.38 – 0.73, P < 0.001; OR 3.36, 95% CI 1.64 – 6.912, P = 0.001). When A-scan parameters were dichotomized according to the identified best-cut off, ACD less than 2.9 mm was strongly related to PG (OR 10.981, 95% CI 1.405 – 85.798, P < 0.001) as well as LT thicker than 4.8 mm (OR 29.245, 95% CI 11.212 – 76.283, P < 0.001).Conclusions: We found that shorter AL, shallow ACD, and thick lens are risk factors for PG.