Biogenic synthesis of silver nanoparticles from marine fungi Aspergillus flavus OQ651270: Their characterization and biological studies

Abstract

Abstract Background Silver nanoparticles (Ag-NPs) have an astounding range of modern applications, which has led to extensive and cutting-edge research and development. Studies on the antibacterial properties of silver nanoparticles (Ag-NPs) were the focus of this work, along with their manufacture, characterization and some biological studies. Results Our extracellular biosynthetic approach to creating Ag-NPs was eco-friendly. Extracts of the marine fungus Aspergillus flavus MK4 were utilized as reducing agents to create the nanoparticles. UV-Visible spectroscopy was used to observe the production of colloidal Ag-NPs. The Plasmon absorbance of the Ag-NPs was observed as a peak in the UV-Visible spectrum at 450 nm. Transmission Electron Microscopy (TEM) techniques were used to characterize the Ag-NPs in terms of size and shape, and the results showed a size range of 15 nm with a spherical shape. Both Gram-negative and Gram-positive bacteria were used to examine Ag-NPs' potential antibacterial effects. All the bacterial strains are demonstrating good antibacterial activity. The cytotoxic activity was tested against the HepG-2 cell line using the MTT assay, while the antioxidant property was analyzed using the radical scavenging (DPPH) assay. Silver nanoparticles synthesized in this way have properties that make them promising for antibacterial, anticancer, and wound-healing uses. Conclusion Aspergillus flavus MK4 has a strong ability to synthesize Ag-NPs, which has been well characterized and has been shown to have good antibacterial, antioxidant, anticancer and wound healing ability.