Affiliation:
1. Southeast University
2. Zhongda Hospital Southeast University
Abstract
Abstract
A large number of clinical and animal studies have demonstrated that osteocalcin (OC) secreted by osteoblasts plays an important role in glucose metabolism. The purpose of this study was to further investigate the correlation between OC and different blood glucose markers in patients with type 2 diabetes.A total of 480 patients were divided into male group(n = 258) and postmenopausal female group(n = 258). OC, Glycated hemoglobin (HbA1c), Glycated albumin (GA) and 1,5-anhydroglucitol (1,5-AG) were measured. The correlation between serum osteocalcin level and different blood glucose markers were analyzed by Spearman correlation analysis and multiple linear regression. Spearman correlation analysis showed that in the male group, the OC level was negatively correlated with HbA1c (r=-0.252, p < 0.001) and GA (r = 0.158, p = 0.011), but positively correlated with 1, 5-AG (r = 0.204, p < 0.001). Similarly, in the postmenopausal female group, the OC level was found to have a negative relation with HbA1c (r=-0.286, p < 0.001) and GA (r=-0.160, p = 0.017), and a positive relation with 1, 5-AG (r = 0.329, p < 0.001). Different models were used to adjust for confounding factors. According to multiple stepwise regression analysis results, OC was an independent factor affecting the HbA1c and 1, 5-AG levels in both the male group and the postmenopausal female group. Serum osteocalcin was correlated with glycemic function in type 2 diabetes mellitus, and could be taken as an independent factor affecting not only long-term blood glucose but also short-term blood glucose, especially the postprandial hyperglycemia state.
Publisher
Research Square Platform LLC
Reference31 articles.
1. Bone as an endocrine organ;Guntur AR;Endocr Pract,2012
2. The Interplay Between Bone and Glucose Metabolism;Cipriani C;Front Endocrinol (Lausanne),2020
3. Osteocalcin–GPRC6A: An update of its clinical and biological multi–organic interactions (Review);Diaz-Franco MC;Mol Med Rep,2019
4. Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone;Hauschka PV;Physiol Rev,1989
5. Endocrine regulation of energy metabolism by the skeleton;Lee NK;Cell,2007