Predictors of postoperative recurrence of pheochromocytoma: A monocentric study

Abstract

Abstract Background To discuss the risk factors affecting the recurrence of pheochromocytoma after surgery. Methods We retrospectively reviewed patients who were hospitalized and underwent surgery for PCC between January 2012 and December 2020 at Chinese PLA General Hospital. Inclusion criteria were pathological diagnosis of PCC and availability of follow up. Results In total, 451 patients met the inclusion criteria. The average age was 45.89 years, and the median tumor diameter was 5.75 cm. The mean recurrence time was 34.24 months. Of the 451 patients receiving surgery, there were 35 recurrent cases (7.85%). The univariate test showed that age, hypertension, history of PCC recurrence, Ki-67 index ≥ 5, bilateral tumor, duration of phenazopyridine administration, DBP at admission, open operation, intraoperative HR minimum, intraoperative times of HR over 120, times of instability, and intraoperative bleeding were associated with recurrence after radical surgery. Multivariate COX regression analysis of age (HR(hazard ratio) 0.95), hypertension (HR 7.14), history of PCC recurrence (HR 69.35), family history of hypertension (HR 16.30), bilateral tumor (HR 7.38), tumor size (HR 1.05), times of instability (HR 114.91) and length of instability in minutes (HR 1.12) were the independent influences on recurrence after pheochromocytoma resection. Conclusions Age, hypertension, history of PCC recurrence, family history of hypertension, bilateral tumor, tumor size, intraoperative times of instability, and intraoperative instability minutes were independent influences on recurrence after pheochromocytoma resection.