Clinical Evaluation of Anti-inflammatory and Analgesic Activities of AQUA-TURM (branded extract of Curcuma longa) in Individuals Suffering from Osteoarthritis of Knee(s): A Randomized, Double Blind, Placebo Controlled clinical study

Abstract

Abstract Background: Anti-inflammatory and analgesic activities of Curcuma longa extract can be helpful in the management of Osteoarthritis. Objectives: to evaluate the anti-inflammatory and analgesic activities of AQUATURM® (branded extract of Curcuma longa) in individuals suffering from Osteoarthritis of Knee joint Methods: In present randomized, double blind, placebo controlled clinical study, a total 60 participants suffering from Osteoarthritis of the knee joint were randomized in two groups through a double-blinded procedure. AQUA-TURM® or its matching placebo was given in a dose of 1 capsule of 250 mg twice daily after meals for 90 days. Of these, 56 subjects completed the study (26 in AQUA-TURM® group and 30 in placebo group). Assessment of comparative change in knee joint pain on VAS, WOMAC Index was done on monthly intervals. Other parameters like time to walk 50 feet, requirement of painkillers, changes in the CRP levels and safety assessment through adverse event monitoring and laboratory parameters was done. Results: A significant reduction (p < 0.05) in pain was observed on VAS scale with the use of AQUA-TURM® as compared to placebo over a period of 90 days. On the WOMAC index, significant reduction (p < 0.05) was observed on the domains of pain and stiffness. A significant reduction was observed on CRP levels. AQUA-TURM® did not produce any significant adverse effects on clinical and laboratory parameters and was well tolerated. Conclusion: Supplementation of AQUATURM® in individuals suffering from Osteoarthritis of Knee joint showed significant reduction in pain and swelling showing its analgesic and anti-inflammatory effect.