Correlation between skeletal muscle mass to visceral fat area ratio,inflammatory factors, and insulin resistance in patients with type 2 diabetes

Abstract

Abstract objective To explore the correlation between Skeletal muscle mass and visceral fat area ratio (Skeletal muscle mass to visceral fat area ratio (SVR), neutrophil/lymphocyte ratio (NLR) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).Methods We investigated the SVR, NLR, and IR in 201 patients with T2DM who visited the Department of Endocrinology of the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine between June 2022 and March 2023. Appendicular skeletal muscle mass (ASM), total body fat (TBF), visceral fat area (VFA), and basal metabolic volume were measured using multifrequency bioimpedance analysis method. The percentage of body fat to body mass (TBF%), appendicular skeletal muscle mass index (ASMI), and SVR were calculated.Results Patients were divided equally into three groups (Q1–Q3) according to SVR levels. Compared with the Q3 group, in both Q1 and Q2 groups, waist-hip ratio, neutrophils, NLR, fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides, total cholesterol, free fatty acid, TBF, TBF%, and VFA were all increased (P < 0.005), whereas lymphocytes, insulin sensitivity index (ISI), ASM, ASMI, basal metabolic rate, and SVR were all decreased (P < 0.005).Conclusion NLR was negatively correlated with ASM, ASMI, SVR, and ISI (P < 0.005) and positively correlated with TBF, TBF%, VFA, and HOMA-IR (P < 0.005). SVR can predict IR in T2DM.