Affiliation:
1. National Institutes of Biomedical Innovation, Health and Nutrition
2. Osaka Metropolitan University
3. Meiji University
Abstract
AbstractMany pathogens acquire pathogenicity through a specialized capacity for metabolic adaptation, but unique adaptations in the metabolism ofCampylobacter jejuniremain to be investigated. Here, we found that cultivation ofC. jejuniunder different conditions resulted in changes to the metabolic pathways associated with their altered pathogenicity in mice, such as highly frequent colonization and subsequent severe inflammation in the intestine. The metabolic changes involved the aspartate transferase–mediated pathway with serine as a substrate, which was required for aerobic energy generation. Our findings propose a novel pathway for controlling the pathogenicity ofC. jejuniwith promising preventive and therapeutic strategies for targeting bacterial metabolism.
Publisher
Research Square Platform LLC
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