Affiliation:
1. Zhengzhou University
2. Huazhong University of Science and Technology
Abstract
AbstractAims Our investigation focused on the associations between isocarbophos and isofenphos with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), as well as how much of these associations might be accounted for by markers of inflammation. Methods There were 2701 participants in a case-control study. Plasma isocarbophos and isofenphos concentrations were measured using gas chromatography and triple quadrupole tandem mass spectrometry. Generalized linear models were used to calculate the relationships between plasma isofenphos and isocarbophos levels with inflammatory factor levels and T2DM. Inflammatory indicators were used as mediators to estimate the mediating effects on the above associations. Results Isocarbophos and isofenphos were positively related with T2DM after adjusting for other factors. The odds ratio (OR) (95% confidence interval (CI)) for T2DM was 4.1% (OR (95% CI): 1.041 (1.015, 1.068)) and the odds ratio (95% CI) for IFG was 6.6% (OR (95% CI): 1.066 (1.009, 1.127)) per unit rise in ln-isocarbophos. The incidence of T2DM increased by 6.4% for every 1 unit more of ln-isofenphos (OR (95% CI): 1.064 (1.041, 1.087)). Additionally, a 100% rise in ln-isocarbophos was linked to 3.3% higher ln-HOMA2IR and a 0.029 mmol/L higher glycosylated hemoglobin A1c (HbA1c) (95% CI: 0.007, 0.051). While a 100% rise in ln-isofenphos was linked to increases in ln-HOMA2 (95% CI: 1.6%, 5.2%) and ln-HOMA2IR (95% CI: 3.6%, 8.1%) of 5.8% and 3.4%, respectively. Furthermore, white blood cell (WBC) and neutrophilic (NE) were found to be mediators in the relationship between isocarbophos and T2DM, and the corresponding proportions were 17.12% and 17.67%, respectively. Conclusion Isofenphos and isocarbophos are associated with IFG and T2DM in the rural Chinese population, and the inflammatory indicators (WBC and NE) have a significant role in this relationship.
Publisher
Research Square Platform LLC
Reference57 articles.
1. WHO. Diabetes. Available from: https://www.who.int/health-topics/diabetes#tab=tab_1.
2. Diabetes and Alzheimer's Disease: Might Mitochondrial Dysfunction Help Deciphering the Common Path?;Potenza MA;Antioxidants (Basel),2021
3. The prevalence and predictors of diabetes distress in elderly with type 2 diabetes mellitus;Azadbakht M;Diabetes Res Clin Pract,2020
4. Prevalence of type 2 diabetes mellitus (T2DM) in the adult Russian population (NATION study);Dedov I;Diabetes Res Clin Pract,2016
5. Young-onset type 2 diabetes mellitus - implications for morbidity and mortality;Magliano DJ;Nat Rev Endocrinol,2020