Relationship between glycemic variability and arrhythmias: protocol for a systematic review and meta-analysis

Abstract

Abstract Introduction Arrhythmias are common in type 2 diabetic patients. The link between blood glucose fluctuations and arrhythmia risk is gaining attention.TThe aim of this systematic review is to investigate the relationship between blood glucose variability and arrhythmia in patients with T2DM and provide more advanced evidence for clinical practice. Methods and analysis PubMed, EMBASE, The Cochrane Library, China Biology Medicine disc, and the Wanfang database online will be included to be searched.We'll look for publications, conference papers, current trials, and internal reports, as well as observational research, by hand (cross-sectional and follow-up studies) written in English or Chinese examining the relationship between abnormal glycemic variability and arrhythmias in patients with T2DM up to 30 June 2021.The articles will be read independently by two reviewers. Information such as first author, time of publication and outcome measures will be extracted. Researchers will also assess the quality of the literature using the Cochrane Handbook's quality assessment criteria. RevMan 5.3.5, EndNote X7, and STATA 13.0 will be utilized for data analysis.We will use extractable data for systematic evaluation at last. Ethics and dissemination: Because this systematic review used published data, no ethical approval was necessary.