Accuracy of Non- Invasive Hemoglobin and Venous Blood Gas Hemoglobin Measurements in Comparison with Laboratory Method in Intensive Care Unit

Abstract

Abstract Background: Continuous real time monitoring of hemoglobin (Hb) may provide clinical valuable information to guide blood transfusion decisions in the intensive care unit (ICU). This study was designed to evaluate non-invasive hemoglobin (SpHb) and venous blood gas (VBGHb) measurement accuracy in comparison to laboratory hematology measurement (LabHb) in ICU. Methods: With each blood gas analysis, SpHb was recorded, and venous blood Hb was measured by hematology (LabHb) and blood gas CO-Oximetry (VBGHb). Results: Compared to LabHb, SpHb showed small bias with better limits of agreement than VBGHb. Mean bias (95% limits of agreement) for SpHb was -0.0557 (-0.5614 to 0.4499) gm/dL and for VBGHb was -0.4734 (-2.8312 to 1.8844). Also for trend accuracy, Modified Bland–Altman analysis showed small bias with better limits of agreement for SpHb trends compared to VBGHb trends. Mean bias (limits of agreement g/dl) for SpHb was -0.0102 (− 0.6317 to 0.6113); for VBGHb was 0.0136 (− 3.5733 to 3.5461). Conclusion: We concluded that Non-invasive hemoglobin (SpHb) showed acceptable absolute and trend accuracy and excellent correlation with Lab-Hb, which provides an easy, feasible and accurate solution for Hb measurement in ICU.