UBE2C is associated with Prognosis of Immunosuppression and Cell Invasiveness in Glioma

Abstract

Abstract Background Glioma is one of the common tumors of the central nervous system, which presents difficulties in clinical diagnosis and treatment due to its characteristics of immunosuppression and cell invasion phenotypes. The condition and prognosis of glioma may be predicted during the process of diagnosis and treatment, it will be more conducive to timely intervention or evaluation of glioma. Methods Differential or risk genes were analyzed based on TCGA (The Cancer Genome Atlas) - glioma samples, selecting relative typical biological processes based on enrichment analysis of their common genes. Target gene UBE2C were obtained by the expression correlation and differential expression analysis for the enrichment results. UBE2C were evaluated by clinical grading, survival prognosis and cell experiments. GSEA (Gene Set Enrichment Analysis) analysis based on GEO (Gene Expression Omnibus) data sets and the above conclusions were verified. The correlation of UBE2C with immune invasion, immune checkpoint and cell invasiveness of gliomas was analyzed by TCGA-glioma data and STRING, respectively. Results Our results suggests that the high expression and risk of UBE2C in gliomas may be a factor that promotes malignant phenotype of tumor cells. The immune phenotype shows that IL6 and IL10 may be the key nodes affecting the immunosuppressive phenotype of glioma. Further, the invasion genes from the MMP family can be correlated with immunosuppressive phenotypes via UBE2C-IL6/IL10 axis, especially displayed by MMP2/MMP9. Conclusion The UBE2C may systemic effects the malignant phenotype, immunosuppression and cell invasiveness of tumors systematically, which reflects UBE2C as a potential biomarker and therapeutic target for glioma.