Abstract
Background:Prior research has demonstrated a correlation between mood swings (MS) and heart failure (HF), as well as a potential link to abdominal obesity. Nevertheless, the precise connections among MS, abdominal obesity, and HF require further investigation for clarification.
Methods: Two-sample Mendelian randomization (MR) was used to analyze the causal relationships between MS and HF, combining five types of cardiovascular diseases (CVDs) risk factors to explore their effects on HF. Multivariable MR analysis was used to exclude confounding factors. A two-step MR approach was used to quantify potential mediating effects of CVDs risk factors in the causal relationships between MS and HF.
Results: Individuals with MS had a significantly higher risk of heart failure (HF) and chronic HF. They also had increased waist-to-hip ratio (WHR), trunk fat mass (TFM), and trunk fat percentage (TFP), which further increased their risk of HF. Mediation effects analysis indicated that in the causal effects of MS on HF, WHR contributed 20.79% (95% CI = -1.83% - 43.42%), TFP contributed 19.10% (95% CI = 2.90% - 35.3%), and TFM contributed 25.02% (95% CI = 5.48% - 44.56%).
Conclusion: WHR, TFM, and TFP respectively play considerable independent mediating roles in the causal effects of MS on the risk of developing HF, and it is possible to indirectly reduce the risk of developing HF associated with MS by managing mood and controlling abdominal obesity.