Correlation between PRSS23 and Prognosis and Immune Regulation in Pancreatic Cancer

Abstract

Abstract Pancreatic cancer (PC) is a highly deadly solid malignant tumors with disrespectful prognosis, making appropriate biomarkers determination extraordinary crucial. Immune infiltration in tumor microenvironment is related to the subsistence of patients in PC. It has not been elaborated that the relationship between serum protease 23 gene (PRSS23) gene and the PC. We first determined the PRSS23 expression and its possible biological roles in PC, then analyses the TCGA and GEO data sets to check the possible carcinogenic effects of PRSS23.Moreover, the clinical value of PRSS23 was clarified through Kaplan-Meier Cox regression and prognostic nomogram model in PC. To examine the possible biological roles of PRSS23, GO analysis and KEGG analyses were accomplished. Using Tumor Immunity Estimation Resource (TIMER), We discover that the PRSS23 expression was raised in the PC tissue compared to corresponding non-cancerous tissue. High-PRSS23 expression is bound up with worse clinical pathological characteristics and worse prognosis in the PC. The correlation between PRSS23 and tumor infiltration was determined in tumor microenvironment (TME). Furthermore, functional enrichment analysis shows that PRSS23 may make a difference in impacting TME, cell adhesion and migration in PC tumor cell. This study maybe the first across-the-board discussion to reveal that the PRSS23 can be used as a new type of biomarker linked with immune infiltration and enlighten latent treatment targets in PC treatment.