Formulation Development and Characterization of Polymeric Nanocarrier Encapsulating Phytoconstituents for The Treatment of Cancer

Abstract

Abstract Herbal medications have emerged as a prominent focus within the pharmaceutical industry due to their well-established efficacy and limited occurrence of adverse effects. Moreover, in contrast to synthetic drugs, herbal medications exhibit a comparable level of interest in the production of nanoparticles. Polymeric nanoparticles have emerged as a crucial method for enhancing medication bioavailability and enabling targeted distribution to the desired location of action. Due to its medicinal properties, which include analgesic, anti-inflammatory, antibacterial, and antioxidant effects. Formulations were prepared using different ingredients using the solvent evaporation method. Polyvinyl alcohol, Polylactic acid was used as a biodegradable polymer, HPMC, Polyvinylpyrrolidone (PVP), and Sucrose. Sunitinib Malate is an active pharmaceutical ingredient that is a receptor tyrosine kinase inhibitor and chemotherapeutic drug. Physalis peruviana was extracted by the maceration method. The extract of the Physalis peruviana was encapsulated, Quercetin is the flavonoid that worked as a main constituent. The current study indicates that Physalis peruviana-loaded nanoparticles assist in the anti-cancer activity effectively.