The chemokine CXCL7 is correlated with LDH-A and predicts the prognosis of patients with colorectal cancer

Abstract

Abstract Objective: The aims of this study were to evaluate the correlation between CXCL7 expression and glycolysis and to explore the prognostic significance of CXCL7 in colorectal cancer (CRC). Methods: The expression of CXCL7 and LDH-A was measured by immunohistochemistry in tissue from 158 CRC patients. Patients were divided into high expression and low expression groups based on receiver operating characteristic curves and a cut-off value. The correlation between CXCL7 and LDH-A expression was evaluated. The overall survival (OS) times of CRC patients were explored. The risk factors related to prognosis were assessed. Results: Significantly higher expression of CXCL7 and LDH-A was detected in CRC tissue than in non-CRC tissue, and was associated with N stage and TNM stage. CXCL7 expression was strongly correlated with LDH-A expression in CRC tissue. High expression of CXCL7 was validated as an independent risk factor for OS. Conclusion: Increased expression of CXCL7 was positively correlated with LDH-A expression and was an independent risk factor for CRC prognosis.