The effect of aloe vera syrup on the components of metabolic syndrome in patients with bipolar disorder type 1

Abstract

Abstract ObjectiveThe aim of this study was to determine the effect of aloe vera syrup on the indicators of metabolic syndrome, anthropometric indices and lipid profile in patients with bipolar disorder type 1.MethodsThis randomized controlled trial was performed on 68 bipolar patients with metabolic syndrome. Patients received aloe vera or placebo syrups for 12 weeks. Assessment of blood pressure, biochemical and anthropometric indices, and physical activity were performed before and after the intervention. Dietary intakes were assessed three times.ResultsThere was no significant difference between groups in most of the baseline characteristics (P > 0.05). Results showed that aloe vera syrup only decreased aspartate aminotransferase significantly (P = 0.02) and had no significant effect on the indicators of metabolic syndrome (P > 0.05), but placebo syrup increased weight and body mass index and decrease diastolic blood pressure significantly (P = 0.006, P = 0.004, P = 0.04 respectively). Aloe vera syrup did not show significant effects on indices compared with placebo (P > 0.05).ConclusionThis clinical trial showed that aloe vera syrup had no significant effect on indicators of metabolic syndrome, anthropometric indices, and lipid profile.Clinical trial registration in Iranian Registry of Clinical TrialsIRCT registration number: IRCT20200429047235N1 (First registration date: 2020-06-06).