Synthesis of Dual-responsive CMC-based Nanogels for Drug Delivery Applications

Author:

Cai Yuanpeng1,Li Danyang1,Peng Shaohua1,Liu Hui1

Affiliation:

1. Central South University

Abstract

Abstract

Nanogels offered a large surface area for biological conjugation due to their nanoscale size, enabling prolonged circulation in the bloodstream and targeted delivery to specific tissues. CMC/POM nanogels composed of 2-(2-(2-methoxyethoxy) ethoxy) ethyl methacrylate (MEO3MA), methacrylic acid (MAA) and natural biopolymer carboxymethyl cellulose (CMC), were synthesized via free radical polymerization. The chemical structures of CMC/POM nanogels were characterized using several techniques and the response behaviors under temperature and pH variations were reflected by changes in turbidity and particle size. The results demonstrated that CMC/POM nanogels exhibited significant changes in particle size and turbidity around 38°C and under different pH conditions. Additionally, the unique microstructure of CMC/POM nanogels made them promising for drug delivery through injection therapy. Choosing doxorubicin (DOX) as a model drug, the nanogels could achieve maximum drug loading content of 31.47% and drug loading efficiency of 62.93%. In vitro controlled drug releasing, the efficiency was up to 92.20% within 24 h at T = 45 ℃ & pH = 3.0. The cytotoxicity assays confirmed that CMC/POM nanogels possessed superior biocompatibility and drug-loaded CMC/POM nanogels effectively inhibited the activity of cancer cells. CMC/POM nanogels displayed remarkable potential as intelligent drug delivery systems and were expected to play an essential role in the field of anticancer therapies.

Publisher

Springer Science and Business Media LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3