A Scale-Up of Fluidized Bed Granulation Process for Calcium-Tryptophan
Author:
Affiliation:
1. CJ CheilJedang Pharmaceutical Business Division: HK inno.N Corp
2. Sung Kyun Kwan University: Sungkyunkwan University
3. Sungkyunkwan University
Abstract
The importance of tryptophan in both human and animal nutrition continues to drive its demand and market growth. The fluidized bed granulation is one of the crucial processes for industrial production of tryptophan from microbial fermentation, particularly as the simplified process of evaporation and granulation to efficiently generate commercial granular products. In this study, solid flow analysis for scaling up fluidized bed granulators in the manufacturing of calcium-tryptophan granules was conducted in terms of solid flow characteristics of the granules, flow regime within the granulator, and design considerations of the granulator. Based on the established scale-up case of calcium-tryptophan granules, it was founded that the flow regime of bubbling fluidization occurred similarly in both pilot and plant scale fluidized bed granulator. Then, the desired height (transport disengaging height, TDH) and entrainment rate (to secure the capacity of entrained particle recovery equipment such as cyclones or bag filters) were determined to obtain basic design data for scale-up of the fluidized bed granulation.
Publisher
Springer Science and Business Media LLC
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