Affiliation:
1. AstraZeneca (United States)
2. Newton South High School
3. University of Georgia
Abstract
Abstract
Three crystalline forms of nicotinamide riboside chloride (NR-Cl), namely Form A, Form B and Form C, were prepared and characterized. Form A and Form B are true polymorphs of anhydrous forms, while Form C is a pseudo-polymorph of a methanolate solvate form. Physical stability relationship among these three crystalline forms was established, and the crystal structure of the most stable form, Form B, was determined by single crystal X-ray diffraction analysis.
Publisher
Research Square Platform LLC
Reference21 articles.
1. Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection;Chi Y;Curr Opin Clin Nutr Metab Care,2013
2. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults;Martens CR;Nat Commun,2018
3. Nicotinamide Riboside—The Current State of Research and Therapeutic Uses;Mehmel M;Nutrients,2020
4. Szczepankiewicz B, Koppetsch K, Perni RB (2015) Preparation and use of crystalline beta-d-nicotinamide riboside. GlaxoSmithKline, p WO2015186068
5. Carlson EC, Standen MC, Morrill WM (2016) Crystalline form of nicotinamide riboside. W. R. Grace & Co. WO2016014927