Affiliation:
1. Northwest School of Medicine
2. Aga Khan University Hospital
3. The Aga Khan University and Medical College
Abstract
Abstract
Background: The standard of care for gliomas includes maximum safe resection of the tumor. This may lead to inadvertent damage to tissue directly or vasculature supplying normal brain tissue. This may result in perilesional brain infarction which is readily seen on early postoperative MRI scans. Their relationship with the presence of a deficit and recovery from said deficit is unclear.
Methods: We did a retrospective chart and radiology review to study this relationship.
Results: Out of 225 included patients, 24% had infarcts on their postoperative MRI while the rest did not have infarcts. The incidence of new deficits in these two groups was not significantly different. The presence of these infarcts did not appear to affect recovery from deficits against patients with deficits and no infarcts. Moreover, the location of the tumor did not significantly correlate with the presence of infarcts, new deficits or recovery from deficits. The extent of resection also failed to show a strong correlation with new infarcts or deficits. Only a small percentage of all patients failed to show some or complete improvement from deficits at 6 months follow up.
Conclusion: Perilesional infarcts are a common finding on postoperative scans after glioma surgery but their presence does not help to predict the presence of a deficit nor the recovery from a deficit.
Publisher
Research Square Platform LLC