Gastrointestinal system endoscopy and pathological findings in non-dialysis chronic kidney disease: A single-centre study

Abstract

Different gastrointestinal complications may occur as a result of moderate and severe loss of kidney function in chronic kidney disease (CKD). This study examined upper gastrointestinal tract endoscopy and pathology findings in CKD patients with renal failure who were not receiving dialysis treatment. Method This study included 60 pre-dialysis CKD patients who underwent endoscopic examination due to dyspeptic complaints (CKD group. Endoscopic and pathological findings were compared with those of non-uremic patients (non-CKD group) with similar complaints. Results There was no difference in the frequency of gastroesophageal reflux in both groups. The rates of non-ulcerative lesions, esophagitis, antral gastritis, erythematous gastritis and active chronic gastritis were significantly higher in the CKD group than in the non-CKD group (p < 0.001). Erosive pangastritis was significantly higher in the non-CKD group. The frequency of ulcerative lesions was similar in both groups. There was no significant difference in the rates of intestinal metaplasia, atrophy and metaplastic gastritis. The frequency of Helicobacter pylori was significantly higher in the non-CKD group (p < 0.001). Conclusion Our findings show that some upper gastrointestinal system disorders are more common in non-dialysis CKD patients than non-uremic individuals, but Helicobacter pylori frequency is lower.