Affiliation:
1. Peking University Cancer Hospital and Institute
2. The First Affiliated Hospital of Liaoning Medical University
Abstract
Abstract
It is well known that immune cells including macrophage within the tumor microenvironment play an essential role in tumor progression. Here, we studied how NFATc2 regulates macrophage properties in lung adenocarcinoma. Positive relationships were found between NFATc2 and genes associated with hypoxia and glycolysis in lung adenocarcinoma from the TCGA dataset. NFATc2 enhanced cell migration and lactate levels in lung adenocarcinoma cells. According to single-cell sequence data, NFATc2 is closely associated with infiltrating immune cells and is related to macrophage polarization. NFATc2 promotes M2 polarization in macrophages. As a transcription factor, NFATc2 binds to the USP17 promoter region. Furthermore, the NFATc2 inhibitor suppressed M2 polarization induced by USP17. In conclusion, NFATc2 promotes lactate levels and M2 polarization of macrophages by transcriptionally regulating USP17 in lung adenocarcinoma.
Publisher
Research Square Platform LLC
Reference31 articles.
1. Cancer statistics, 2023, CA: a cancer journal for clinicians;Siegel RL,2023
2. Paz-Ares, Lung cancer: current therapies and new targeted treatments;Hirsch FR;Lancet,2017
3. Bejarano L, Jordao MJC, Joyce JA. Therapeutic Target Tumor Microenvironment Cancer Discov. 2021;11:933–59.
4. Macrophage targeting: opening new possibilities for cancer immunotherapy;Cassetta L;Immunology,2018
5. Progress in tumor-associated macrophage (TAM)-targeted therapeutics;Ngambenjawong C;Adv Drug Deliv Rev,2017