LINC00937 acts bi-function in oral squamous cell carcinoma cell growth and immune cell infiltration regulated FGR/IL10RA axis

Abstract

Abstract LINC00937 is a long non-coding RNA (lncRNA) up-regulated in multiple human carcinomas, such as oral squamous cell carcinoma (OSCC). However, the significance and potential mechanisms of LINC00937 in OSCC progression are still primarily need discussed. In our study, we first showed the part of LINC00937 in OSCC progress, and our data showed that LINC00937 has up-regulated in The Cancer Genome Atlas (TCGA) datasets and OSCC tissues. At the same time, LINC00937 is located in the cell nucleus. Up-regulate level of LINC00937 was correct with advanced clinical survival as well as HPV expression. Receiver operating curve (ROC) results showed the diagnostic ability of LINC00937 (AUC = 0.712) in OSCC patients. Meanwhile, LINC00937 is positively correct with FGR and IL10RA expression, downstream genes for LINC00937 in OSCC progress by PPI. In addition, pathway analysis showed LINC00937 was correlated with immune infiltrated cells relative-singling pathways. Finally, the silence of LINC00937 suppresses OSCC cell growth, induces apoptosis, inhibits migration, and invades in vitro. Our findings demonstrated that LINC00937 regulates expression of the downstream gene (FGR/IL10RA) and then regulates cell growth as well as metastasis in OSCC. Our data proved a piece of evidence that LINC00937 could serve as a prognostic biomarker for OSCC controlling immune infiltration.