Abstract
Reproduction success in oviparous animals is determined by the optimum vitellogenin deposition in the follicles. Vitellogenin is synthesized by hepatocytes under estrogen stimulation. Hepatocytes functionalities are important to produce vitellogenin. This research was designed to increase liver functions by using catfish as a model. The hepatocyte function is improved by katuk extract, turmeric powder, and vitamin C supplementations. The experiment consisted of 8 treatments and 3 repetitions. The treatments were given for 8 weeks. Parameters measured were Hepatosomatic Index (HSI), histology of the liver, concentrations of serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), and superoxide dismutase (SOD). The results showed that HSI in catfish supplemented with combination of katuk extract, turmeric powder, and vitamin C showed the highest values. The liver histology in catfish supplemented with turmeric powder showed the lowest level of hepatocyte vacuolization compared to all treatments without turmeric supplementation. The SOD values were increased in the groups of catfish supplemented with turmeric powder with SGPT and SGOT values decreased compared to catfish without turmeric powder supplementation. It is concluded that turmeric powder supplementation can improve the hepatocytes capacities and functionalities to support vitellogenin synthesis to be deposited in the growing and developing oocytes.