Faecalibacterium prausnitzii Reduces Plasma Lipopolysaccharide and Inhibits Atherosclerosis

Author:

Yang Hai-Tao1,Liu Jing-Kun1,Wu Ting-Ting1,Yang Yi1,Wu Cheng-Xin1,Hou Xian-Geng1,Zheng Ying-Ying1,Ma Yi-Tong1,Xie Xiang1

Affiliation:

1. First Affiliated Hospital of Xinjiang Medical University

Abstract

Abstract Background The gut microbiota is related to the occurrence and development of coronary artery disease (CAD). However, the specific target of gut microbiota in preventing CAD is rarely reported. The aim of this study was to identify important specific targets through metagenomics and untargeted metabolomics and to verify their relationships with atherosclerosis. Methods A total of 371 participants with CAD of varying severity and controls without CAD were recruited. Then, metagenomic sequencing and untargeted metabolite sequencing were used to search for important markers in faecal samples. Mice predisposed to atherosclerosis were then used to investigate the underlying mechanisms of the relationship between these species and atherosclerosis. Results The results of faecal metagenomics sequencing and untargeted metabolite sequencing in the CAD group and control group showed that the population with a high abundance of Faecalibacterium prausnitzii(F. prausnitzii) had the lowest incidence of CAD, and random forest importance analysis also revealed the relationship between F. prausnitzii and CAD. Moreover, we also found that F. prausnitzii was equally effective in predicting CAD alone. F. prausnitzii reduced the formation of atherosclerotic lesions in ApoE−/− mice by gavage. The mechanism involves reduction of the synthesis level of intestinal LPS and improvement of intestinal permeability by strengthening the mechanical barrier and mucosal barrier to reduce the level of plasma LPS, leading to systemic inflammation and local inflammatory reactions in the aorta, thus achieving an anti-atherosclerotic effect. Conclusions Sequencing of the samples identified a previously unknown link between specific gut microbiota and atherosclerosis. Treatment with F. prausnitzii may help prevent CAD.

Publisher

Research Square Platform LLC

Reference37 articles.

1. The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on Cardiovascular Health and Diseases Burden in China: an Updated Summary of 2020. Chinese Circulation Journal. 2021; June, Vol. 36 No.6(Serial No.276).

2. Association of Hospital-Level Differences in Care With Outcomes Among Patients With Acute ST-Segment Elevation Myocardial Infarction in China;Xu H;JAMA Netw Open,2020

3. Next-generation probiotics: a promising approach towards designing personalized medicine;Singh TP;Crit Rev Microbiol,2021

4. Evolving trends in next-generation probiotics: a 5W1H perspective;Almeida D;Crit Rev Food Sci Nutr,2020

5. Faecalibacterium prausnitzii-derived microbial anti-inflammatory molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression;Xu J;J Diabetes,2020

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3