Accidental Ingestion of Isoniazid Causing Toxicity in a Dog: a Case Report

Abstract

Abstract A seven month old male spitz dog was presented with history of accidental ingestion of Isoniazid tablets. On presentation, signs of seizures, involuntary defecation and urination, vomiting and excess salivation were noticed. Clinical examination revealed tachycardia, ataxia, increased respiratory rate, congested mucus membrane and severe dehydration. Immediately, therapy was aimed at stabilization of the dog with fluid therapy, anticonvulsants (Diazepam) and antidote i.e., Pyridoxine. The clinical signs subsided in four hours of therapy. Complete blood profile revealed hemoconcentration, mild neutrophilia, hypoproteinemia, elevated BUN, creatinine and ALP values. The dog was kept under observation for 48 hours. After 24 hours of therapy, apart from vomiting no other clinical signs were noticed. Fluid therapy along with anti-emetics, proton pump inhibitors and oral pyridoxine was administered for two more days following first day. The dog showed complete recovery on day three of therapy and the biochemical values were back to normal on seventh day. The present case reports a dog with accidental oral ingestion of Isoniazid, its clinical signs and therapeutic management.