BE-WEL Trial (Breast: Evaluation of Weight and Exercise for Lymphoedema) Testing weight control and exercise programmes for women with breast cancer related lymphoedema: a feasibility trial

Abstract

Abstract Purpose A combined body weight loss and upper body / arm exercise programme is a potential effective management for Breast cancer related lymphoedema (BCRL), but there is limited data on its efficacy, or the best way it could be delivered. Methods Fifty–seven women with overweight/obesity and BCRL were randomised to a supervised (n = 12) or home-based combined weight loss and upper body/arm exercise programme (n = 16), a home-based upper-body arm exercise only programme (n = 17) or standard care (n = 12). Results Sixteen percent of women invited joined the study. Reductions in weight occurred in the supervised and home-based weight control and exercise programmes; Mean (95% CI) change compared to standard care -1.68 (-4.36 to -1.00), -2.47(-4.99 to -0.04)Kg. Reductions in perometer assessed BCRL were seen in the supervised and home-based combined weight control and arm exercise groups and the weight stable home-based arm exercise only group: Mean (95% CI) change compared to standard care -96(-185 to -6), -61(-144 to +22), -77 (-159 to + 4)ml. There was no correlation between changes in the perometer and the bio impedance electrical analysis (BEA) measurements R=0.068 (P=0.49). Conclusion Supervised and home-based weight control and exercise programmes led to modest changes in weight and reductions in BCRL which were comparable to a weight stable group undertaking arm exercise only. Bioelectrical impedance does not appear to be a good measure of changes in BCRL with weight loss and upper body resistance exercise.