Measurement of Static and Dynamic Pupillary Characteristics after Implantable Collamer Lens with a Central Hole (ICL V4c) by Sirius Anterior Segment Analysis System

Abstract

Abstract Background To investigate the static and dynamic pupillometry characteristics before and after ICL V4c implantation under different light conditions. Methods This prospective study involved 210 consecutive high myopia patients undergoing implantation of a V4c ICL. Sirius anterior eye segment analysis system (CSO, Florence, Italy) was used for pupillometry preoperatively and 2 weeks, 1 month, and 3 months after surgery. Static pupillometry measurements (pupil diameter at 3 standardized illumination levels) and dynamic parameters (including initial pupil diameter, minimum pupil diameter after light stimulation, and velocity of dilation) were measured. Results Under the scotopic, mesopic and photopic conditions, PD decreased significantly after ICL implantation and restored to the preoperative level 1–3 months after surgery. Initial PD and minimum PD after light stimulation at all time points after surgery had no statistical differences, and the velocity of pupil dilation showed no significant changes at the observed time points. Under three light conditions, all pupil center coordinates shifted toward infra-temporal sites after surgery, and pupil center coordinates gradually approached cornea center after surgery. The scotopic and photopic vaults at the observed time points after ICL implantation were positively correlated with scotopic, mesopic, and photopic PD, while they were not correlated with initial pupil, minimum PD after light stimulation, the velocity of pupil dilation within 1 second, 2 seconds and 1–2 seconds after light stimulation. Conclusions ICL V4C implantation has an effect on pupil diameter in the early postoperative period, pupil diameter became smaller under the photopic, mesopic and scotopic conditions, but restored to the preoperative level about 1–3 months after surgery under the three conditions. Trial registration: The ethics committee of Zhengzhou University’s First Affiliated Hospital gave its approval to this study (2021-KY-0872-002).