Abstract
Background: Previous studies have examined the relationship between hypertension or homocysteine and chronic kidney disease (CKD). However, the relationship between H-type hypertension and CKD remains uncertain. The aim of this study was to investigate the relationship between H-type hypertension and CKD and to provide a scientific basis for the prevention and treatment of CKD;
Methods: This case-control study included 514 study subjects, 257 in each of the case and control groups. The diagnostic criteria for CKD were structural or functional abnormalities of the kidneys for ≥ 3 months, which may or may not be accompanied by a decrease in eGRF, and which may be manifested by abnormalities of pathology or indicators of renal injury (including blood urine and composition or imaging tests). All patients were categorized into normal, Hcy (Hcy ≥10 μmol/L), hypertensive, and H-type hypertension groups according to their Hcy levels and whether they had hypertension.Univariate analysis and multivariate logistic regression models were used to assess the association between H-type hypertension and CKD, and subgroup analyses were performed for potential confounders;
Results: The differences between the CKD group and the control group in terms of age, education, exercise, BMI, TG, HDL, UA, Scr, BUN and hs-CRP were statistically significant (p < 0.05).Logistic regression modeling showed that after correcting for confounders, we found that the H-type hypertension group had the highest risk of CKD (OR=4.453; 95% CI: 2.075-9.560; P<0.001). There was no interaction of H-type hypertension with age, education level, physical activity, or TG on the development of CKD(P＞0.05);
Conclusions: The coexistence of Hcy and hypertension increases the risk of developing CKD, and H-type hypertension is a risk factor for CKD.