Exposure to Oral Contraceptives Alters Human Endometrial Stem Cells Culture Media Metabolomics-Reference-Cited by-同舟云学术

Exposure to Oral Contraceptives Alters Human Endometrial Stem Cells Culture Media Metabolomics

Published:2022-12-29 Issue: Volume: Page:
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Author:

Rochetti Raquel Cellin¹,Cordeiro Fernanda Bertuccez²,Costa Livia do Vale Teixeira da¹,Fraietta Renato¹,Perkel Kayla Jane³,Ferreira Fernando Prado¹,Turco Edson Guimaraes Lo¹

Affiliation:

1. Sao Paulo Federal University

2. Escuela Superior Politécnica del Litoral

3. University of Guelph

Abstract

Abstract PURPOSE: Endometrial plasticity relies on endometrial mesenchymal stem cells (EnMSC), while the influence of oral contraceptives (OCs) in these cells is unknown. OBJECTIVES: Investigate the influence of OCs in EnMSC metabolism by culture media analysis. METHOD: The EnMSC were collected from menstrual shedding and cultured for three passages. Culture media was collected at the end of each passage for further metabolomics. RESULTS: The OC and non-OC groups differed significantly in their metabolites profile, indicated by 15 metabolites with discriminant power for sample classification. CONCLUSIONS: Altered metabolomic profiling may be an effect of OC hormonal properties on EnMSC metabolism.

Publisher

Research Square Platform LLC

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