Oxidative stress-related markers as prognostic factors for patients with primary sclerosing cholangitis in Japan

Author:

Oyama Atsushi1ORCID,Takaki Akinobu2,Adachi Takuya2,Wada Nozomu2,Takeuchi Yasuto2,Onishi Hideki2,Shiraha Hidenori2,Okada Hiroyuki2,Otsuka Motoyuki2

Affiliation:

1. "Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka Igakubu"

2. Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka Igakubu

Abstract

Abstract Background/purpose: Primary sclerosing cholangitis (PSC) is a rare chronic liver disease. The mechanisms and prediction of progression for PSC are unclear. Recent investigations have shown that general conditions, such as oxidative stress, affect the course of chronic diseases. We investigated the clinical course and oxidative stress-related condition of PSC to determine the prognostic factors. Methods We recruited 58 patients with PSC (median age; 34.5 years, median observation period; 33.5 months) who visited our department from 2003 to 2021. Clinical characteristics were investigated to define the prognostic factors. The oxidative stress status was evaluated using two types of markers: an oxidative stress marker (serum reactive oxygen metabolite; dROM) and an antioxidant marker (serum OXY adsorbent test; OXY). Results The revised Mayo risk and Child–Pugh scores or fibrosis-related FIB-4 index were able to significantly discriminate patients with poor overall survival. High intestinal immunoglobulin (Ig) A levels predicted poor survival. In patients with high or intermediate revised Mayo risk scores, those with high dROM levels showed better survival than those with lower dROM levels. The serum OXY showed no such correlations. In this population, dROM was negatively correlated with AST and IgA, which are both correlated with survival. Conclusions High or intermediate revised Mayo risk score predicted poor PSC clinical course. Additionally, the Child–Pugh score and FIB-4 index were significantly correlated with survival. In patients with high or intermediate revised Mayo risk scores, low oxidative stress status correlated with high IgA and exhibited poor prognosis.

Publisher

Research Square Platform LLC

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