Affiliation:
1. The First Affiliated Hospital of Chongqing Medical University
2. Chongqing Public Health Medical Center
Abstract
Abstract
Background
The purpose of this study was to compare the differences in oncological features, surgical safety and prognosis between HIV positive CRC patients and HIV negative CRC patients with the same T stage and the same tumor site.
Patients and Methods
We collected a total of 24 patients with HIV infection combined with CRC who underwent radical resection of CRC. With the method of random stratified sampling, A total of 363 postoperative patients with colorectal adenocarcinoma without HIV infection were collected. After propensity score matching(PSM), we got 72 patients (HIV+∶HIV-=24∶48). The differences of perioperative serological indexes, surgical safety, oncological features and long-term prognosis were compared.
Results
Of 363 HIV negative CRC patients, 48 HIV negative patients were matched with 24 HIV positive patients. Compared with HIV negative patients, less HIV positive patients received chemotherapy, HIV+ patients had fewer preoperative leukocytes, fewer postoperative leukocytes, fewer preoperative lymphocytes, lower CEA, more intraoperative bleeding, more metastatic lymph nodes, higher N stage, higher TNM stage, shorter overall survival and shorter progression free survival.
Conclusion
Compared with HIV negative CRC patients, HIV positive patients with the same T stage and the same tumor site have more metastatic lymph nodes and worse long-term survival after surgery, but the risk of surgery will not increase.
Publisher
Research Square Platform LLC