Porvac® subunit vaccine induces neutralizing antibodies against all three main classical swine fever virus genotypes

Abstract

The classical swine fever is endemic and a major health problem for the swine industry in Cuba. The current efforts to control the disease include vaccination with Porvac®, a subunit marker vaccine. Although the efficacy of Porvac^® against subgenotype 1.4 has been extensively documented, little is known about the abilty of the antibodies induced by this vaccine to neutralize other genotypes. Sera collected frm three pigs vaccinated with Porvac^® were able to efficiently neutralize CSFV strains belonging to genotypes 1, 2 and 3. Porvac^®-induced antibodies also neutralized bovine viral diarrhea virus and border disease virus. The results suggest that Porvac^® marker vaccine could be used for controlling CSF globally.