Gram-Scale Synthesis of Heterogeneous Cu-MOFs Catalyst with Dual Functionalities for Late-stage Dicarbofunctionalization of Alkenes

Author:

Guo Shuo1,Dong Lu1,Chen Hu1,Tan Xiaoli1,Sun Wei2,Feng Rui3ORCID,Jia Yanyuan1

Affiliation:

1. Inner Mongolia University

2. University of Michigan

3. Nankai University

Abstract

Abstract

Multifunctional catalysts in organic synthesis are highly attractive, particularly in the construction of complex molecules. Here, we report the first example of heterogeneous Cu-MOFs catalyst with dual functions of photoredox and cross-coupling. IMU-108 can be synthesized on a gram scale from Cu(NO3)2·3H2O and 5-mercaptoisophthalic acid precursors by a simple reflux process. X-ray diffraction results revealed that IMU-108 is constructed from the in-situ bridged S-S bond between the zero-dimension metal-organic polyhedra (MOPs). The inter-polyhedras S-S bonds not only create a rigid geometric structure, but also allow IMU-108 to be bench-stable, while still maintaining excellent catalysis. We demonstrate the capacity of IMU-108 in heterogeneous photoredox-catalyzed cross-coupling of styrenes, α-carbonyl alkyl and bromides with boronic acids to yield various substituted 1,1-diarylalkanes in a single step. The versatility of this method enables late-stage functionalization of complex molecules without the need for de novo synthesis. Moreover, IMU-108 exhibits good recyclability, maintaining its catalytic activity over six consecutive reaction cycles.

Publisher

Research Square Platform LLC

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