Traditional Chinese medicine based integrated health interventions for depression: A systematic review and meta-analysis

Abstract

Abstract Background: Some Traditional Chinese medicine (TCM)-based integrated health interventions have been used for depression, but pooled efficacy remains unknown. Aims and objectives: This study aimed to systematically evaluate the efficacy of TCM-based integrated health interventions for relieving depression. Design: Systematic review and meta-analysis. Methods: A comprehensive literature search was conducted on 17 databases from inception up to June 2022. Randomized controlled trials (RCTs) that examined an integrated health intervention based on TCM theory for depression were included. The risk of bias was assessed using the second version of the Cochrane risk-of-bias tool for randomized trials, and the quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation system. Results: Eighteen RCTs with a total of 1,448 depressed participants were included. Health care providers, mainly nurses (14 studies), implemented TCM-based integrated health interventions. The pooled results showed that TCM-based integrated health interventions had larger effects on reducing depressive symptoms (15 studies; standardized mean difference = −2.05; 95% CI: −2.74, −1.37; p < 0.00001) compared with usual care at posttreatment but showed no significant difference contrasted to cognitive behavioral therapy (two studies, p = 0.31). However, the overall evidence was low. Conclusions: The meta-analysis results indicated that TCM-based integrated health interventions were effective in reducing depression. However, the results should be interpreted with caution because of the low quality of the included studies. Future RCTs with rigorous designs should be conducted to provide robust evidence of the efficacy of TCM-based integrated health interventions in treating depression.