Comparison of the effect of propolis vaginal gel and metronidazole oral tablet on wet smear test results in women suffering from trichomoniasis

Author:

Taghavian Shadi1,Beiranvand Reza2,Valiani Mahboubeh1,Alian Siamak3,Yekdaneh Afsaneh1,Tehrani Hatav Gasemi1,Zafarbakhah Azam1,Brojeni Tahere Khalili1

Affiliation:

1. Isfahan University of Medical Sciences

2. Khomein University of Medical Sciences

3. R&D Member of Daroodarman Pharmacy Company

Abstract

Abstract Background and objective: Trichomoniasis is the most common non-viral sexually transmitted infection. One of the methods for diagnosing trichomoniasis is a wet smear test. Propolis has anti-parasitic properties are due to its components, namely tannins, flavonoids, and volatile oils. The present study was performed to compare the effect of a vaginal gel containing propolis extract with that of a metronidazole oral tablet on the wet smear test results in women suffering from trichomoniasis. Material and method: The present clinical trial was performed on 102 married non-pregnant women with trichomoniasis, who were referred to obstetrics and gynecology clinics in Isfahan from September 15 to January 20, 2020. The patients were assigned into two groups of intervention and control randomly. Both groups underwent treatment for 7 days. Wet smear was taken from the patients three times (i.e. initial visit, first follow-up, and second follow-up) and the samples were observed under Carl Zeiss single-lens microscope. Data were analyzed using SPSS (version 20) at a significance level of 0.05. Results: Two groups did not differ significantly in terms of baseline characteristics. In the first post-treatment follow-up, the chance of a negative wet smear test result was 4.41 times greater in the intervention group than in the control group. Given the control of the baseline characteristics, this chance was 5.8 times greater. In addition, it was found that the chance of a negative wet smear test result in the second follow-up was affected by the wet smear test result in the first follow-up. Conclusion: Based on the results of this study, it can be concluded that vaginal gel containing 7.5% propolis extract was more efficient than standard treatment in eradicating infection and preventing the recurrence of infection.

Publisher

Research Square Platform LLC

Reference29 articles.

1. The evaluation of pain in neurosurgical patients before and after operation in Kerman Shahid Bahonar Hospital according to the McGill pain questionnaire;Ebrahimi-Nejad G;J Kerman Univ Med Sci,2004

2. Frequency of Trichomonas vaginalis infection among pregnant women referred to health and medical centers in Ardabil city, 2013–2014;Mohammadi-ghalehbin B;J Ardabil Univ Med Sci,2015

3. Makhlay N, editor New test for sensitivity evaluation of Trichomonas vaginalis to nitroimidazoles and nitrofurans in vitro. BMC Proceedings; 2011: BioMed Central.

4. Clinical performance of the Solana® Point-of-Care Trichomonas assay from clinician-collected vaginal swabs and urine specimens from symptomatic and asymptomatic women;Gaydos C;Expert Rev Mol Diagn,2017

5. The Prevalence of Trichomoniasis in Women Referring to Health Treatment Centers in Karaj City, 2016 (Iran);Bakhtiyar Nejad S;Qom Univ Med Sci J,2018

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