Predictive Value of Maternal Systemic Inflammatory Markers in Treatment- Requiring Retinopathy of Prematurity

Abstract

Abstract Purpose To investigate the predictive values of maternal systemic inflammatory markers, such as the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), systemic immune-inflammatory index (SII), platelet mass index (PKI), and mean platelet volume (MPV), in treatment-requiring retinopathy of prematurity (TR-ROP). Methods The mothers of the 21 preterm infants who were followed up due to ROP but did not require treatment and the mothers of preterm infants who received ROP treatment (intravitreal injection) (19 patients) were included in the treatment group. The birth weights (BW) and gestational ages (GA) of the infants were recorded. A prenatal maternal complete blood count (CBC) analysis was performed within 3 days before birth. NLR, PLR, LMR, SII, PCI and MPV data were calculated and compared statistically from the complete blood count (CBC) samples of the mothers of the preterm infants who did or did not need ROP treatment. The results were evaluated by adjusting them with logistic regression analysis. Results There was no significant difference between the groups in terms of BW (p = 0.108). The GA was significantly lower in the TR-ROP group compared to the control group (p = 0.04, 26.5 (24–33), 29 (27–32), respectively). Between TR-ROP and control groups, NLR (p = 0.02, 5.9 (3.2–12.9), 4.2 (0.9–11.8)), PLR (p = 0.02, 136.4 ± 27.6, 111.1 ± 37.1), LMR (p = 0.001, 2.06 (1.1–4.2), 3.01 (1.2–5.9)) and SII (p = 0.001) values were significantly different. In the TR-ROP group, when these values were corrected with GA in logistic regression analysis, NLR, PLR, and SII were not statistically significant (p = 0.11, p = 0.83, and p = 0.14), but there was an increase in LMR [p = 0.02, OR = 0.38 95% CI (0.16–0.88)]. Conclusion The prenatal maternal LMR was found to have a statistically significant predictive value for TR-ROP. In the prenatal period, a maternal systemic inflammatory state may be a risk factor for ROP development in the premature baby. Prenatal maternal LMR may be a guide for infants with TR-ROP. Babies who are thought to be at higher risk of TR- ROP may be screened more frequently.