Association between serum copper and stroke in general population: A Nationally Representative Study

Abstract

Abstract OBJECTIVES: We aim to explore the association between serum copper and prevalence of stroke in American adults. METHODS: Data were obtained from 3 consecutive National Health and Nutrition Examination Survey (NHANES) cycles (2011-2016). Weighted multivariate logistic regression analysis was conducted to evaluate the association between serum copper and self-reported stroke. RESULTS: A total of 5,151 adults met the inclusion criteria for this study. A total of 181 (3.51%) stroke cases were identified. Compared with the lowest tertile (<16.4 umol/l), odds ratio(OR) and 95% confidence interval (CI) for participants in middle tertile(16.4-19.8 umol/l) and highest tertile (>19.8 umol/l) of serum copper were 0.99(95%CI: 0.44-2.25) and 2.36(95%CI: 1.01-5.52), respectively. Per standard deviation (SD) increment of serum copper was positively associated with the prevalence of stroke (OR: 1.44, 95%CI: 1.11-1.86). Dose-response analysis showed a positive linear association between serum copper and stroke (Pnonlinearity=0.554). CONCLUSIONS: This cross-sectional study suggest a positive association between serum copper and the prevalence of stroke in American adults.